The effects of manganese overexposure on brain health
| Autor: | Comfort O.A. Okoh, Nicole Aranoff, Michael Aschner, Olayemi K. Ijomone, Mahfuzur R. Miah, Omamuyovwi M. Ijomone, Ayodele J. Akinyemi, Félix Alexandre Antunes Soares, Bárbara Nunes Krum, Grace T. Akingbade, Tao Ke, Aaron B. Bowman, Airton Cunha Martins |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Pollution media_common.quotation_subject chemistry.chemical_element Manganese medicine.disease_cause Article 03 medical and health sciences Cellular and Molecular Neuroscience Human health 0302 clinical medicine Air Pollution Occupational Exposure medicine Animals Humans media_common Chemistry Manganese Poisoning Neurotoxicity Brain Cell Biology medicine.disease Oxidative Stress 030104 developmental biology Increased risk Environmental chemistry Occupational exposure 030217 neurology & neurosurgery Oxidative stress Mn toxicity |
| Zdroj: | Neurochem Int |
| ISSN: | 0197-0186 |
| Popis: | Manganese (Mn) is the twelfth most abundant element on the earth and an essential metal to human health. Mn is present at low concentrations in a variety of dietary sources, which provides adequate Mn content to sustain support various physiological processes in the human body. However, with the rise of Mn utility in a variety of industries, there is an increased risk of overexposure to this transition metal, which can have neurotoxic consequences. This risk includes occupational exposure of Mn to workers as well as overall increased Mn pollution affecting the general public. Here, we review exposure due to air pollution and inhalation in industrial settings; we also delve into the toxic effects of manganese on the brain such as oxidative stress, inflammatory response and transporter dysregulation. Additionally, we summarize current understandings underlying the mechanisms of Mn toxicity. |
| Databáze: | OpenAIRE |
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