Effects of voriconazole on tacrolimus metabolism in a kidney transplant recipient
| Autor: | Giuliano Polichetti, Massimo Sabbatini, Vincenzo Basile, Giovanni Tarantino, A.L. Ciotola, Stefano Federico, Michele Santangelo, Riccardo Nappi, Vincenzo d'Alessandro, Antonio Gentile, Domenico Capone, Andrea Renda |
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| Přispěvatelé: | Capone, Domenico, Tarantino, Giovanni, Gentile, Antonio, Sabbatini, Massimo, Polichetti, G, Santangelo, Michele, Nappi, Riccardo, Ciotola, A, D'Alessandro, V, Renda, Andrea, Basile, Vincenzo, Federico, Stefano |
| Rok vydání: | 2010 |
| Předmět: |
Adult
medicine.medical_specialty Antifungal Agents medicine.medical_treatment therapeutic drug monitoring chemical and pharmacologic phenomena Pharmacology Organ transplantation Tacrolimus medicine Cytochrome P-450 CYP3A Humans Pharmacology (medical) Drug Interactions Enzyme Inhibitors Kidney transplantation Voriconazole medicine.diagnostic_test Chemistry tacrolimu Immunosuppression Triazoles medicine.disease Kidney Transplantation drug metabolism Calcineurin Transplantation surgical procedures operative Pyrimidines Treatment Outcome Therapeutic drug monitoring Cytochrome P-450 CYP3A Inhibitors Kidney Failure Chronic Drug Therapy Combination Female Drug Monitoring Immunosuppressive Agents medicine.drug |
| Zdroj: | Journal of clinical pharmacy and therapeutics. 35(1) |
| ISSN: | 1365-2710 |
| Popis: | Infection occurs frequently in the organ transplant recipients during the post-transplant period because of immunosuppression. Therefore, prophylactic antimicrobial agents are often used. The azole antifungals, widely prescribed prophylactically, are known to have many drug-drug interactions. This report presents a case of drug-drug interaction between voriconazole and tacrolimus in a kidney transplant recipient. Voriconazole treatment led to a dramatic increase in tacrolimus concentration that required its discontinuation in spite of the manufacturer's guidelines that recommend a reduction of tacrolimus dosage by one-third. The present drug-drug interaction can be attributed to a strong inhibitory effect on cytochrome P450-3A4 activity by voriconazole. When voriconazole and tacrolimus are coadministered, close monitoring of tacrolimus blood levels is recommended as the rule-of-thumb reduction of tacrolimus dose by one-third may not be satisfactory. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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