Characterisation of the canine cardiac sarcolemma in experimental myocardial ischemia
| Autor: | K. G. Nair, T. F. Ashavaid, T. J. Netticadan |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty Pathology Myocardial ischemia Sarcolemma Heart Diseases business.industry Calcium pump Clinical Biochemistry Ischemia Fatty acid medicine.disease Oleic acid chemistry.chemical_compound Enzyme Endocrinology chemistry Internal medicine medicine cardiovascular system Carnitine business medicine.drug |
| Zdroj: | Indian journal of clinical biochemistry : IJCB. 12(1) |
| ISSN: | 0970-1915 |
| Popis: | The cardiac sarcolemma was characterized in 13 normal and 11 ischemic dog hearts by enzyme analysis and compositional assays. Significant decreases in the activities of the sodium-potassium and calcium pumps and structural compositional disturbances were observed in ischemia. High concentrations of oleic acid, a fatty acid and palmitoyl carnitine, a fatty acid intermediate caused inhibition of the enzyme pump activities of the normal sarcolemma. Thus, ischemia results in the functional impairment of the sarcolemma. Accumulation of fatty acid and fatty acid intermediates, occurring in myocardial ischemia, could be an underlying mechanism. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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