Viral load is strongly associated with length of stay in adults hospitalised with viral acute respiratory illness
| Autor: | Martin D. Curran, Marie-Jo Medina, Sally Batham, Sean Ewings, Surendra Parmar, Tristan W Clark, Karl G. Nicholson |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Adult Male medicine.medical_specialty Influenza vaccine viruses 030106 microbiology Polymerase Chain Reaction Virus Article law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Internal medicine Influenza Human medicine Hospitalisation Adults Humans 030212 general & internal medicine Respiratory system Intensive care medicine Respiratory Tract Infections Aged Aged 80 and over Respiratory viruses Respiratory illness Acute respiratory illness business.industry Coinfection Length of Stay Middle Aged Viral Load medicine.disease Comorbidity Infectious Diseases Virus Diseases Acute Disease Viruses Multiple linear regression analysis Female business Viral load |
| Zdroj: | The Journal of Infection |
| Popis: | Summary Background Respiratory viruses are detectable in a large proportion of adults hospitalised with acute respiratory illness. For influenza and other viruses there is evidence that viral load and persistence are associated with certain clinical outcomes but it is not known if there is an association between viral load and hospital length of stay. Methods 306 adults hospitalised with viral acute respiratory illness were studied. Associations between viral load and length of stay were examined. Multiple linear regression analysis was performed to control for age, comorbidity, influenza vaccine status, duration of illness prior to hospitalisation, bacterial co-infection, clinical group and virus subtype. Results High viral load was associated with a longer duration of hospitalisation for all patients (p Highlights • It is not known if viral load is associated with length of stay in viral acute respiratory illness. • We examined 306 adult patients hospitalised with confirmed viral acute respiratory illness. • High viral load was associated with longer length of stay for all virus subtypes and all clinical groups. • This could be used in clinical practise to identify high risk patients and prioritise antivirals. |
| Databáze: | OpenAIRE |
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