Experimental treatment ofBrucella melitensis infection in sheep with oxytetracycline alone or combined with streptomycin
| Autor: | Samir M. Hafez, Abdel Karim Al-Aska, Ahmed I. Radwan, Saad I. Bekairi, Abdullah A. Al-Mukayel, Mohammad J.M.S Al-Yamani, Mohammad Al-Jalaifi |
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| Rok vydání: | 1989 |
| Předmět: |
Veterinary medicine
Sheep Diseases Oxytetracycline Biology Brucellosis Random Allocation Food Animals Pregnancy medicine Animals Pregnancy Complications Infectious Random allocation Sheep Brucella melitensis infection Inoculation Abortion Veterinary biology.organism_classification medicine.disease Every Three Days Streptomycin Drug Therapy Combination Female Animal Science and Zoology Infertility Female Brucella melitensis medicine.drug |
| Zdroj: | Tropical Animal Health and Production. 21:211-216 |
| ISSN: | 1573-7438 0049-4747 |
| DOI: | 10.1007/bf02250836 |
| Popis: | The efficacy of oxytetracycline (OTC) alone or combined with streptomycin in the treatment of 118 Najdi ewes believed to have been naturally infected with Brucella melitensis, was evaluated by culture of selected tissues and organs at slaughter. Groups of sheep were given 250, 500 or 1,000 mg of OTC intraperitoneally (i/p) daily for six weeks and in the respective groups at necropsy 52, 69 and 100% of sheep were found to be Brucella-free. Treatment with 250 mg OTC (daily for six weeks i/p) combined with 1,000 mg streptomycin (daily for three weeks intramuscularly) increased the percentage of Brucella-free sheep to 82%. When a group of sheep were each inoculated i/p with 1,000 mg of long-acting OTC every three days over a period of six weeks, 75% of them were Brucella-free at necropsy. B. melitensis was isolated from all (24) non-treated (control) sheep. The results showed that long-term treatment with a high dose of OTC alone had succeeded in eliminating B. melitensis from a group of 16 naturally infected sheep. |
| Databáze: | OpenAIRE |
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