Long-term Outcomes of Antiviral Therapy in Patients With Advanced Chronic HBV Infection
| Autor: | Kwang Hyub Han, Si Hyun Bae, Hye Won Lee, Dong Joon Kim, Jin-Woo Lee, Jae Youn Cheong, Byung Ik Kim, Yeon Seok Seo, Sang Hoon Ahn, Ja Kyung Kim, Jun Yong Park, Tae Yeob Kim, Jung Hyun Kwon, Byoung Kuk Jang, Hyung Joon Yim, Sang Gyune Kim, Moon Young Kim, Sung Min Myoung, Won Young Tak, Soung Won Jeong, Ki Tae Yoon, So Young Kwon |
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| Rok vydání: | 2019 |
| Předmět: |
Liver Cirrhosis
Male medicine.medical_specialty Carcinoma Hepatocellular Guanine Viremia Disease Esophageal and Gastric Varices medicine.disease_cause Antiviral Agents Gastroenterology 03 medical and health sciences Liver disease Hepatitis B Chronic 0302 clinical medicine Fibrosis Internal medicine medicine Humans In patient Hepatitis B e Antigens Hepatitis B virus Hepatology business.industry Liver Neoplasms Antiviral therapy Middle Aged Viral Load medicine.disease Thrombocytopenia Lamivudine 030220 oncology & carcinogenesis Hepatocellular carcinoma Splenomegaly Female 030211 gastroenterology & hepatology business |
| Zdroj: | Clinical Gastroenterology and Hepatology. 17:2811-2813.e1 |
| ISSN: | 1542-3565 |
| DOI: | 10.1016/j.cgh.2019.01.044 |
| Popis: | Hepatitis B virus (HBV) suppression with nucleot(s)ide analogue therapy reduces the risk of hepatic decompensation and hepatocellular carcinoma (HCC) in patients with advanced liver disease.1 In the present era of potent antiviral therapies, the prognostic significance of the serum HBV DNA level as a biological gradient has substantially diminished; the majority of treated patients achieve virologic suppression.2,3 After control of viremia, a higher baseline fibrosis level is a useful predictor for disease progression.4 Few "prospective" studies on the effects of antiviral agents, especially in chronic hepatitis B (CHB) patients with advanced liver disease, have been reported. |
| Databáze: | OpenAIRE |
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