Increased epicardial adipose tissue in type 1 diabetes is associated with central obesity and metabolic syndrome
| Autor: | Isabela Bussade, Marcio Antonio Epifanio, Denise Prado Momesso, Luis Augusto Tavares Russo, Rosane Kupfer, Claudio Domenico Sahione Schettino |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
medicine.medical_specialty Intra-Abdominal Fat Endocrinology Diabetes and Metabolism Coronary Artery Disease Body Mass Index Coronary artery disease Endocrinology Absorptiometry Photon Classification of obesity Risk Factors Internal medicine Diabetes mellitus Internal Medicine medicine Body Fat Distribution Humans Adiposity Metabolic Syndrome Type 1 diabetes business.industry Incidence General Medicine Middle Aged medicine.disease Obesity Cross-Sectional Studies Diabetes Mellitus Type 1 Echocardiography Obesity Abdominal Hypertension Female Metabolic syndrome business Body mass index Pericardium Biomarkers Brazil |
| Zdroj: | Diabetes research and clinical practice. 91(1) |
| ISSN: | 1872-8227 |
| Popis: | Aims The present study evaluated the relationship between metabolic syndrome (MS), body fat composition and epicardial adipose tissue (EAT) in type 1 diabetes. Epicardial adipose tissue is a new independent marker of coronary artery disease (CAD). Methods Forty-five type 1 diabetic women were evaluated (age 36 ± 9 years; body mass index 24.6 ± 4.4 kg/m2). Metabolic syndrome was defined by the World Health Organization criteria. Body fat composition and EAT were analyzed by dual-energy-X-ray absorptiometry and echocardiogram, respectively. Results Twenty patients (45%) had MS. Patients with MS had greater android (central) fat deposition than patients without MS (41.9 ± 2.0% vs. 33.7 ± 1.8%, p = 0.004). Total body fat and gynoid (peripheric) fat distribution were similar between the groups. Mean EAT was higher in patients with MS (6.15 ± 0.34 mm vs. 4.96 ± 0.25 mm; p = 0.006) and EAT was positively correlated with android (central) fat distribution (r = 0.44; p = 0.002), however no correlation was found with gynoid (peripheric) fat distribution. Conclusions There was a high incidence of MS in type 1 diabetes related to increased central adiposity, despite the absence of obesity. Metabolic syndrome and central obesity were associated with increased EAT. Thus, young non-obese type 1 diabetic women with central adiposity and/or MS may have increased EAT, what may predict CAD risk. |
| Databáze: | OpenAIRE |
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