Specific targeting of intestinalPrevotella copriby aListeria monocytogenesbacteriocin
| Autor: | Hannah Fehlner-Peach, Massimo Marzorati, Dan R. Littman, Jana De Bodt, Tom Van de Wiele, Marion Bérard, Marc Lecuit, Pascale Cossart, Marie-Anne Nahori, Benoit Chassaing, Alexandra Moura, Olivier Dussurget, Nathalie Rolhion, Andrew T. Gewirtz |
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| Rok vydání: | 2019 |
| Předmět: |
0303 health sciences
biology 030306 microbiology Mutant Inflammation biology.organism_classification medicine.disease_cause Listeria infection medicine.disease Commensalism 3. Good health Microbiology 03 medical and health sciences Listeria monocytogenes Bacteriocin medicine Listeria Prevotella medicine.symptom 030304 developmental biology |
| DOI: | 10.1101/680801 |
| Popis: | Deciphering the specific function of every microorganism in microbial gut communities is a key issue to interrogate their role during infection. Here, we report the discovery of aListeriabacteriocin, Lmo2776, that specifically targets the abundant gut commensalPrevotella copriand affectsListeriainfection. Oral infection of conventional mice with a Δlmo2776mutant leads to a thinner intestinal mucus layer and higherListerialoads both in the intestinal content and deeper tissues compared to WTListeria, while no difference is observed in germ-free mice. This microbiota-dependent effect is phenocopied by precolonization of germ-free mice beforeListeriainfection, withP. copri, but not with other commensals,. Together, these data unveil a role forPrevotellain controlling intestinal infection, highlighting that pathogens may selectively deplete microbiota to avoid excessive inflammation. |
| Databáze: | OpenAIRE |
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