Attenuated Phenotype of a Recent House Finch-Associated Mycoplasma gallisepticum Isolate in Domestic Poultry
| Autor: | K M Kerr, X. Liao, Dana M. Hawley, K. Pflaum, Edan R. Tulman, J. Beaudet, Keila V. Dhondt, André A. Dhondt, David H. Ley, Steven J. Geary |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Mycoplasma gallisepticum animal structures 040301 veterinary sciences Immunology Virulence Microbiology 0403 veterinary science 03 medical and health sciences biology.animal medicine Animals Mycoplasma Infections Pathogen reproductive and urinary physiology Phylogeny Finch biology Host (biology) Virginia Respiratory pathogen Bacterial Infections 04 agricultural and veterinary sciences biology.organism_classification Virology Phenotype 030104 developmental biology Infectious Diseases medicine.anatomical_structure nervous system behavior and behavior mechanisms Female Parasitology Finches Chickens Respiratory tract |
| Zdroj: | Infection and Immunity. 85 |
| ISSN: | 1098-5522 0019-9567 |
| DOI: | 10.1128/iai.00185-17 |
| Popis: | Mycoplasma gallisepticum , known primarily as a respiratory pathogen of domestic poultry, has emerged since 1994 as a significant pathogen of the house finch ( Haemorhous mexicanus ) causing severe conjunctivitis and mortality. House finch-associated M. gallisepticum (HFMG) spread rapidly and increased in virulence for the finch host in the eastern United States. In the current study, we assessed virulence in domestic poultry with two temporally distant, and yet geographically consistent, HFMG isolates which differ in virulence for house finches—Virginia 1994 (VA1994), the index isolate of the epidemic, and Virginia 2013 (VA2013), a recent isolate of increased house finch virulence. Here we report a significant difference between VA1994 and VA2013 in their levels of virulence for chickens; notably, this difference correlated inversely to the difference in their levels of virulence for house finches. VA1994, while moderately virulent in house finches, displayed significant virulence in the chicken respiratory tract. VA2013, while highly virulent in the house finch, was significantly attenuated in chickens relative to VA1994, displaying less-severe pathological lesions in, and reduced bacterial recovery from, the respiratory tract. Overall, these data indicate that a recent isolate of HFMG is greatly attenuated in the chicken host relative to the index isolate, notably demonstrating a virulence phenotype in chickens inversely related to that in the finch host. |
| Databáze: | OpenAIRE |
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