Correlation between the tumoral expression of beta3-integrin and outcome in cervical cancer patients who had undergone radiotherapy
| Autor: | Yitzhak Zimmer, Ruslan Hlushchuk, C Stiefel, Ueli Studer, Richard H. Greiner, Valentin Djonov, H J Altermatt, J. Hess, Daniel M. Aebersold, Günther Gruber |
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| Rok vydání: | 2004 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Pathology Multivariate analysis cervical cancer radical radiotherapy medicine.medical_treatment Brachytherapy Cell Integrin Uterine Cervical Neoplasms Adenocarcinoma Disease-Free Survival 03 medical and health sciences 0302 clinical medicine Internal medicine Clinical Studies Biomarkers Tumor Medicine Humans Neoplasm Metastasis Receptor 030304 developmental biology Cervical cancer 0303 health sciences biology business.industry Univariate Integrin beta3 Middle Aged medicine.disease Prognosis 3. Good health Radiation therapy medicine.anatomical_structure Treatment Outcome 030220 oncology & carcinogenesis Multivariate Analysis biology.protein Carcinoma Squamous Cell Female business β3-integrin expression |
| Zdroj: | British Journal of Cancer |
| ISSN: | 0007-0920 |
| Popis: | Integrins are cell-surface receptors, which mediate cell-to-cell and cell-to-extracellular matrix adhesion. Besides playing an important role in tumour angiogenesis, beta3-integrin is also expressed in several types of epithelial cancer cells. It was the purpose of the present study to evaluate the prognostic value of beta3-integrin expression in patients with cervical cancer. Biopsies were taken from 82 patients with squamous cell or adenocarcinomas of the uterine cervix who had undergone external-beam radiotherapy with or without brachytherapy. These tissue samples were analysed immunohistochemically for the expression of beta3-integrin. The impact of immunoreactivity for beta3-integrin on survival end points was assessed by univariate and multivariate analyses, and its correlation with clinicopathological characteristics evaluated by crosstabulations. beta3-integrin was expressed in 61% (50 of 82) of the patients. Kaplan-Meier curves revealed local progression-free survival, distant metastasis-free survival and cause-specific survival to be significantly shorter (P-values according to the log-rank test: 0.002, 0.04 and 0.01, respectively) in patients with beta3-integrin expression. The prognostic impact of this parameter was even higher than for other well-known prognostic parameters and remained statistically significant in the multivariate analyses. beta3-integrin, which is expressed in the majority of patients with advanced cervical cancer, has a significant prognostic impact on outcome according to univariate and multivariate analyses. |
| Databáze: | OpenAIRE |
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