Dissociating the causal role of left and right dorsal premotor cortices in planning and executing bimanual movements – A neuro-navigated rTMS study

Autor: Asif Jamil, Kim van Dun, Michael A. Nitsche, Stefanie Verstraelen, Koen Cuypers, Ensiyeh Ghasemian-Shirvan, Siel Depestele, Raf Meesen, Sybren Van Hoornweder, Shanti Van Malderen, Stephan P. Swinnen
Přispěvatelé: VERSTRAELEN, Stefanie, Nitsche, Michael, VAN DUN, Kim, DEPESTELE, Siel, VAN HOORNWEDER, Sybren, JAMIL, Asif, GHASEMIAN SHIRVAN, Ensiyeh, Swinnen, Stephan, VAN MALDEREN, Shanti, CUYPERS, Koen, MEESEN, Raf
Rok vydání: 2021
Předmět:
Adult
dorsal premotor cortex
Dorsum
medicine.medical_specialty
Movement
Repetitive transcranial magnetic stimulation
medicine.medical_treatment
Biophysics
Functional Laterality
050105 experimental psychology
lcsh:RC321-571
Premotor cortex
03 medical and health sciences
0302 clinical medicine
Physical medicine and rehabilitation
medicine
Humans
0501 psychology and cognitive sciences
Bimanual coordination
Interhemispheric interaction
Virtual lesion
Dorsal premotor cortex
Movement quality
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
interhemispheric interaction
Motor planning
General Neuroscience
05 social sciences
Motor Cortex
repetitive transcranial magnetic stimulation
Hand
Transcranial Magnetic Stimulation
virtual lesion
Transcranial magnetic stimulation
medicine.anatomical_structure
Child
Preschool
Neurology (clinical)
Psychology
Psychomotor Performance
030217 neurology & neurosurgery
Zdroj: Brain stimulation, 14(2):423-434
Brain Stimulation, Vol 14, Iss 2, Pp 423-434 (2021)
ISSN: 1935-861X
DOI: 10.1016/j.brs.2021.02.006
Popis: BACKGROUND: The dorsal premotor cortex (PMd) is a key region in bimanual coordination. However, causal evidence linking PMd functionality during motor planning and execution to movement quality is lacking. OBJECTIVE: We investigated how left (PMdL) and right PMd (PMdR) are causally involved in planning and executing bimanual movements, using short-train repetitive transcranial magnetic stimulation (rTMS). Additionally, we explored to what extent the observed rTMS-induced modulation of performance could be explained by rTMS-induced modulation of PMd-M1 interhemispheric interactions (IHI). METHODS: Twenty healthy adults (mean age ± SD = 22.85 ± 3.73 years) participated in two sessions, in which either PMdL or PMdR was targeted with rTMS (10 Hz) in a pseudo-randomized design. PMd functionality was transiently modulated during the planning or execution of a complex bimanual task, whereby the participant was asked to track a moving dot by controlling two dials. The effect of rTMS on several performance measures was investigated. Concurrently, rTMS-induced modulation of PMd-M1 IHI was measured using a dual-coil paradigm, and associated with the rTMS-induced performance modulation. RESULTS: rTMS over PMdL during planning increased bilateral hand movement speed (p = 0.03), thereby improving movement accuracy (p = 0.02). In contrast, rTMS over PMdR during both planning and execution induced deterioration of movement stability (p = 0.04). rTMS-induced modulation of PMd-M1 IHI during planning did not predict rTMS-induced performance modulation. CONCLUSION: The current findings support the growing evidence on PMdL dominance during motor planning, as PMdL was crucially involved in planning the speed of each hand, subserving bimanual coordination accuracy. Moreover, the current results suggest that PMdR fulfills a role in continuous adjustment processes of movement. ispartof: BRAIN STIMULATION vol:14 issue:2 pages:423-434 ispartof: location:United States status: published
Databáze: OpenAIRE
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