Elevated monocyte distribution width in COVID-19 patients: The contribution of the novel sepsis indicator
| Autor: | Danilo Tacconi, Raffaele Scala, Guendalina Vaggelli, Alessandro Pancrazzi, Angelo Galano, Agostino Ognibene, Giovanni Iannelli, Pasqualino Magliocca, Emanuela Tripodo, Alessandro Polcini Tartaglia, Marco Feri, Maria Lorubbio |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Population Pneumonia Viral Clinical Biochemistry Disease Biochemistry Monocytes Article Sepsis 03 medical and health sciences Betacoronavirus 0302 clinical medicine Internal medicine Medicine Humans education Pandemics Monocyte distribution width Whole blood Aged Cell Size Biochemistry medical education.field_of_study business.industry Clinical Laboratory Techniques SARS-CoV-2 Monocyte Biochemistry (medical) COVID-19 Emergency department General Medicine Middle Aged medicine.disease 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Female business Coronavirus Infections |
| Zdroj: | Clinica Chimica Acta Clinica Chimica Acta; International Journal of Clinical Chemistry |
| ISSN: | 0009-8981 |
| DOI: | 10.1016/j.cca.2020.06.002 |
| Popis: | Highlights • Laboratory diagnostic parameters in symptomatic Covid19 disease patients. • Monocyte distribution width and monocyte modification in infection disease and sepsis. • SARS COV2 infection, prognosis in severe respiratory failure with multiple organ failure, clinical and laboratory finding. Introduction Interesting results regarding the contribution of MDW (Monocyte Distribution Width) in the Infectious Disease Unit have been reported. An observational study is ongoing at San Donato Hospital with the aim to evaluate the contribution of MDW in the diagnostic pathway in adult patients entering in the ED setting and tested for SARS-CoV-2. Material and method COVID-19 symptomatic and paucisymptomatic patients presenting to ED (Emergency Department), have been enrolled consecutively. Whole blood venous samples have been collected on K2 EDTA for MDW determination, at the same time a nasopharyngeal swab for SARS-CoV-2 RNA detection have been collected. Results One hundred six patients were negative for SARS-CoV-2 with MDW mean value of 20.3 ± 3.3, while forty-one were positive for SARS-CoV-2 with higher MDW mean value of 27.3 ± 4.9 (P |
| Databáze: | OpenAIRE |
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