XAMOTEROL IN AUTONOMIC AND INTRINSIC SINUS NODE DYSFUNCTION
| Autor: | Wiek H. van Gilst, Jan W. Viersma, Maarten P. van den Berg, Kong I. Lie |
|---|---|
| Přispěvatelé: | Cardiovascular Centre (CVC) |
| Jazyk: | angličtina |
| Rok vydání: | 1990 |
| Předmět: |
Male
Pacemaker Artificial medicine.medical_specialty Xamoterol Propranolol Partial agonist Propanolamines chemistry.chemical_compound Double-Blind Method Internal medicine Heart rate medicine Humans Arrhythmia Sinus Pindolol Sinus (anatomy) Aged Randomized Controlled Trials as Topic Sinoatrial Node business.industry Adrenergic beta-Agonists Middle Aged Pathophysiology Atropine medicine.anatomical_structure Autonomic Nervous System Diseases chemistry Anesthesia Electrocardiography Ambulatory Cardiology Female Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | American Journal of Cardiology, 65(11), 814-816. EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC |
| ISSN: | 0002-9149 |
| Popis: | In a recent study, pindolol, due to its intrinsic sympathomimetic activity or partial agonism, appeared to be of some benefit in the treatment of sinus node (SN) dysfunction. 1 Xamoterol is a cardioselective β-adrenoceptor partial agonist. However, the degree of partial agonism is substantially higher in xamoterol than in pindolol; 43 versus 30%. 2 In this study the effect of xamoterol on heart rate and pacemaker activity was evaluated in patients with SN dysfunction in whom a VVI pacemaker was implanted previously because of incapacitating symptoms. In addition, autonomic blockade with propranolol and atropine 3 was carried out to determine the underlying pathophysiologic mechanism (intrinsic or autonomic SN dysfunction) and to relate these findings to the effect of xamoterol. |
| Databáze: | OpenAIRE |
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