Physicochemical and elemental studies of Hydrocotyle javanica Thunb. for standardization as herbal drug
| Autor: | Vivekananda Mandal, Narendra Nath Ghosh, Debabrata Misra, Manab Mandal |
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| Rok vydání: | 2017 |
| Předmět: |
Drug
lcsh:Arctic medicine. Tropical medicine lcsh:RC955-962 media_common.quotation_subject 030231 tropical medicine chemistry.chemical_element Physico-chemical analysis Antibacterial efficacy 01 natural sciences Biochemistry Genetics and Molecular Biology (miscellaneous) law.invention 03 medical and health sciences Hydrocotyle javanica Thunb 0302 clinical medicine law Botany lcsh:QH301-705.5 media_common Solvent system Hydrocotyle javanica Chromatography biology Biomedical significance Chemistry Heavy metals contents Heavy metals biology.organism_classification 0104 chemical sciences Mercury (element) 010404 medicinal & biomolecular chemistry lcsh:Biology (General) Mineral and elemental compositions Herbal drug Extraction methods Atomic absorption spectroscopy |
| Zdroj: | Asian Pacific Journal of Tropical Biomedicine, Vol 7, Iss 11, Pp 979-986 (2017) |
| ISSN: | 2221-1691 |
| Popis: | Objective: To explore the leaves of Hydrocotyle javanica Thunb. as a source of safe and effective antibacterial herbal medicine. Methods: The standardization was validated by stepwise physicochemical studies, element analysis, determination of ash values, fluorescence analysis, assessment of moisture content, extractive values in different solvent systems and extraction methods. Heavy metal contents, mineral and element contents were analysed by atomic absorption spectrophotometry, inductively coupled plasma-mass spectrometer and CHNS/O analyser, respectively. Results: The methanol extract of the folklore medicinal plant having antibacterial efficacy contained flavonoids and phenolic OH groups. The ICP multi standard indicated the presence of three major compounds with molecular mass of 161190 and 221 Da. Heavy metals viz. lead, mercury and copper content were 4.38 ppm, < 0.05 ppm and 24.70 ppm, respectively. Minerals content of calcium, phosphorus, potassium and iron were 1190.94 mg/100 g, 375.57 mg/100 g, 2820 mg/100 g and 340.20 mg/100 g of plant sample, respectively. Elements like carbon, hydrogen, nitrogen and sulphur contents were 38.18%, 5.67%, 2.23% and 0.51%, respectively. Heavy metal profile of the tested plant was within the permissible limits of the regulatory authorities. Conclusions: Hence the present physicochemical and elements studies reveals that the plant Hydrocotyle javanica Thunb. could be a potent source of herbal preparation as well as a safe and novel synthetic antibacterial drug. |
| Databáze: | OpenAIRE |
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