Longitudinal Changes in Scotopic and Mesopic Macular Function as Assessed with Microperimetry in Patients With Stargardt Disease: SMART Study Report No. 2
| Autor: | Isabelle Audo, Michel Michaelides, Eberhart Zrenner, Alexander Ho, Michael S. Ip, Janet S. Sunness, Sheila K. West, Artur V. Cideciyan, David G. Birch, Millena Bittencourt, Ann-Margaret Ervin, Srinivas R. Sadda, Mohamed Ibrahim-Ahmed, Rupert W. Strauss, Hendrik P. N. Scholl, Xiangrong Kong |
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| Rok vydání: | 2022 |
| Předmět: |
Fovea Centralis
medicine.medical_specialty genetic structures Mesopic vision Visual Acuity ABCA4 Article Macular Degeneration Study report Ophthalmology medicine Humans Stargardt Disease Prospective Studies Scotopic vision Prospective cohort study biology business.industry medicine.disease eye diseases Macular function Stargardt disease Cross-Sectional Studies biology.protein Visual Field Tests ATP-Binding Cassette Transporters sense organs business Microperimetry Tomography Optical Coherence |
| Zdroj: | Am J Ophthalmol |
| ISSN: | 0002-9394 |
| DOI: | 10.1016/j.ajo.2021.10.014 |
| Popis: | PURPOSE: To estimate and compare cross-sectional scotopic versus mesopic macular sensitivity losses measured by microperimetry, and to report and compare the longitudinal rates of scotopic and mesopic macular sensitivity losses in ABCA4 gene associated Stargardt Disease (STGD1). DESIGN: Multicenter prospective cohort study. METHODS: PARTICIPANTS: 127 molecular confirmed STGD1 patients enrolled from 6 centers in the USA and Europe and followed every 6 months for up to 2 years. OBSERVATION PROCEDURES: The Nidek MP-1S device was used to measure macular sensitivities of the central 20° under mesopic and scotopic conditions. The mean deviations (MD) from normal for mesopic macular sensitivity for the fovea (within 2° eccentricity) and extrafovea (4°−10° eccentricity), and the MD for scotopic sensitivity for the extrafovea were calculated. Linear mixed effects models were used to estimate mesopic and scotopic changes. MAIN OUTCOME MEASURES: Baseline mesopic mean deviation (mMD) and scotopic MD (sMD) and rates of longitudinal changes in the mMDs and sMD. RESULTS: At baseline, all eyes had larger sMD, and the difference between extrafoveal sMD and mMD was 10.7 dB (p |
| Databáze: | OpenAIRE |
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