Points regarding cell transplantation for the treatment of spinal cord injury
| Autor: | Kenji Kanekiyo, Chizuka Ide |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Stromal cell locomotor improvement Schwann cell Connective tissue Biology nervbone marrow stromal cell choroid plexus epithelial cell neural stem/progenitor cell axonal regeneration clinical application intrinsic regeneration ability lcsh:RC346-429 Glial scar 03 medical and health sciences 0302 clinical medicine Developmental Neuroscience Neurotrophic factors medicine Spinal cord injury lcsh:Neurology. Diseases of the nervous system Invited Review Spinal cord medicine.disease Transplantation 030104 developmental biology medicine.anatomical_structure nervous system Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neural Regeneration Research, Vol 11, Iss 7, Pp 1046-1049 (2016) Neural Regeneration Research |
| ISSN: | 1673-5374 |
| DOI: | 10.4103/1673-5374.187021 |
| Popis: | Transplantation of somatic cells, including bone marrow stromal cells (BMSCs), bone marrow mononuclear cells (BMNCs), and choroid plexus epithelial cells (CPECs), enhances the outgrowth of regenerating axons and promotes locomotor improvements. They are not integrated into the host spinal cord, but disappear within 2-3 weeks after transplantation. Regenerating axons extend at the spinal cord lesion through the astrocyte-devoid area that is filled with connective tissue matrices. Regenerating axons have characteristics of peripheral nerves: they are associated with Schwann cells, and embedded in connective tissue matrices. It has been suggested that neurotrophic factors secreted from BMSCs and CPECs promote “intrinsic” ability of the spinal cord to regenerate. Transplanted Schwann cells survive long-term, and are integrated into the host spinal cord, serving as an effective scaffold for the outgrowth of regenerating axons in the spinal cord. The disadvantage that axons are blocked to extend through the glial scar at the border of the lesion is overcome. Schwann cells have been approved for clinical applications. Neural stem/progenitor cells (NSPCs) survive long-term, proliferate, and differentiate into glial cells and/or neurons after transplantation. No method is available at present to manipulate and control the behaviors of NPSCs to allow them to appropriately integrate into the host spinal cord. NPSP transplantation is not necessarily effective for locomotor improvement. |
| Databáze: | OpenAIRE |
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