Physical Exercise and Longitudinal Trajectories in Alzheimer Disease Biomarkers and Cognitive Functioning
| Autor: | Anne M. Fagan, Jason Hassenstab, Tammie L.S. Benzinger, Yuxuan Jin, John C. Morris, Denise Head, Carlos Cruchaga, Marta Stojanovic |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Physical exercise tau Proteins Neuropsychological Tests Article 03 medical and health sciences 0302 clinical medicine Physical medicine and rehabilitation Apolipoproteins E Cognition Alzheimer Disease Surveys and Questionnaires medicine Aerobic exercise Verbal fluency test Humans 030212 general & internal medicine Longitudinal Studies Exercise physiology Cognitive decline Exercise Aged Amyloid beta-Peptides business.industry Brain-Derived Neurotrophic Factor Middle Aged medicine.disease Executive functions Psychiatry and Mental health Clinical Psychology Positron-Emission Tomography Female Geriatrics and Gerontology Alzheimer's disease business Gerontology 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | Alzheimer Dis Assoc Disord |
| ISSN: | 1546-4156 |
| Popis: | Introduction Associations of physical exercise with Alzheimer disease (AD) biomarkers and cognitive functioning have been observed cross-sectionally. However, the effects of exercise on longitudinal change in AD biomarkers have not been thoroughly investigated. The current study examined whether individuals with higher baseline exercise exhibited less longitudinal change in AD biomarkers and cognitive functioning, and whether APOE and/or brain-derived neurotrophic factor (BDNF) genotypes moderated the effects of exercise on longitudinal changes. Methods Clinically normal individuals completed a questionnaire on physical exercise over the prior 10-year period at baseline. Ninety-five individuals had serial cerebrospinal fluid samples collected to examine Aβ42, ptau181 and total tau; 181 individuals underwent multiple assessments of amyloid positron emission tomography imaging with Pittsburgh Compound-B; 327 individuals underwent multiple cognitive assessments, including measures of episodic memory, executive functions, verbal fluency, and processing speed. Results Greater exercise was associated with less steep decline in processing speed. Baseline exercise did not robustly impact longitudinal change for any other outcomes. Neither APOE nor BDNF genotype robustly moderated the effect of exercise on trajectories of AD biomarkers or cognitive decline. Interpretation Results suggest that self-reported physical exercise may be limited as a moderator of changes in AD biomarkers. |
| Databáze: | OpenAIRE |
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