Eryloside F, a novel penasterol disaccharide possessing potent thrombin receptor antagonist activity

Autor:	Paul Stead, David Langley, Nicholas L. Taylor, Philip J. Sidebottom, Andrew D. Roberts, Stephen Edward Hiscox, Nicholas B. Pike, Phil S. Robinson, Amy E. Wright, Shirley A. Pomponi
Rok vydání:	2000
Předmět:	Stereochemistry Carboxylic acid medicine.medical_treatment Clinical Biochemistry Disaccharide Pharmaceutical Science Biochemistry Steroid chemistry.chemical_compound Lanosterol Thrombin Drug Discovery medicine Animals Humans Molecular Biology chemistry.chemical_classification Organic Chemistry Antagonist Biological activity Saponins In vitro Porifera Enzyme chemistry Molecular Medicine Receptors Thrombin medicine.drug HeLa Cells
Zdroj:	Bioorganicmedicinal chemistry letters. 10(7)
ISSN:	0960-894X
Popis:	We report the discovery of Eryloside F, a novel disaccharide of the steroidal carboxylic acid penasterol, isolated from an extract of the marine sponge Erylus formosus. The compound is a potent thrombin receptor antagonist, and furthermore inhibits human platelet aggregation in vitro.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cc63f661b782acdacc8e719f76816ae https://pubmed.ncbi.nlm.nih.gov/10762048 Zobrazit plný text záznamu Full Text from ScienceDirect