Mechanisms and therapeutic potentials of cancer immunotherapy in combination with radiotherapy and/or chemotherapy
| Autor: | Xiaochen Wang, Jiang Xu, Jun Li, Guan Sun, Wei-Di Yu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty T-Lymphocytes medicine.medical_treatment Cancer Vaccines Immunotherapy Adoptive 03 medical and health sciences Antineoplastic Agents Immunological Lymphocytes Tumor-Infiltrating 0302 clinical medicine Acquired resistance Immune system Cancer immunotherapy Neoplasms Internal medicine Tumor Microenvironment medicine Animals Humans Chemotherapy business.industry Abscopal effect Cancer Immunotherapy medicine.disease Radiation therapy 030104 developmental biology Chemotherapy Adjuvant 030220 oncology & carcinogenesis Radiotherapy Adjuvant Tumor Escape business |
| Zdroj: | Cancer Letters. 452:66-70 |
| ISSN: | 0304-3835 |
| DOI: | 10.1016/j.canlet.2019.02.048 |
| Popis: | Immunotherapies based on T cells have gained significant success in the treatment of diverse cancers, however, several limitations also exist, including low response, acquired resistance and severe side effects, which lead to unfavorable outcomes. Recent studies found that traditional therapies, radiotherapy and/or chemotherapy may affect the immune condition in situ and cause abscopal effect, which may improve the response of immunotherapies, enhance the efficiency, and reduce the untoward effect. Here, we review the mechanisms uncovering the cancer immunotherapy and immunogenic effects of radiotherapy and chemotherapy, aiming to highlight the principles underlying the therapeutic potentials of cancer immunotherapy in combination with radiotherapy and/or chemotherapy and ultimately guide better designs for future synergistic cancer therapies. |
| Databáze: | OpenAIRE |
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