Maximum standardized uptake value from quantitative bone single-photon emission computed tomography/computed tomography in differentiating metastatic and degenerative joint disease of the spine in prostate cancer patients
| Autor: | Mohd Fazrin Mohd Rohani, Norazlina Mat Nawi, Wan Fatihah Wan Sohaimi, Marianie Musarudin, Hazlin Hashim, Syed Ejaz Shamim, M A Said, Wan Mohd Nazlee Wan Zainon |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Single Photon Emission Computed Tomography Computed Tomography Partial volume Standardized uptake value Single-photon emission computed tomography Technetium Tc 99m Medronate 030218 nuclear medicine & medical imaging Diagnosis Differential 03 medical and health sciences Prostate cancer Joint disease 0302 clinical medicine Image Interpretation Computer-Assisted Medicine Cutoff Humans Radiology Nuclear Medicine and imaging Spinal Neoplasms medicine.diagnostic_test Receiver operating characteristic business.industry Area under the curve Prostatic Neoplasms Biological Transport General Medicine medicine.disease Spine 030220 oncology & carcinogenesis Joint Diseases business Nuclear medicine |
| Zdroj: | Annals of nuclear medicine. 34(1) |
| ISSN: | 1864-6433 |
| Popis: | Qualitative interpretation in bone scan is often complicated by the presence of degenerative joint disease (DJD), especially in the elderly patient. The aim of this study is to compare objectively 99mTc-MDP tracer uptake between DJD and osseous metastases of the spine using semi-quantitative assessment with SPECT SUV. Bone scan with SPECT/CT using 99mTc-MDP was performed in 34 patients diagnosed with prostate carcinoma. SPECT/CT was performed based on our institutional standard guidelines. SUVmax based on body weight in 238 normal vertebrae visualized on SPECT/CT was quantified as baseline. A total of 211 lesions in the spine were identified on bone scan. Lesions were characterized into DJD or bone metastases based on its morphology on low-dose CT. Semi-quantitative evaluation using SUVmax was then performed on 89 DJD and 122 metastatic bone lesions. As most of the bone lesions were small in volume, the effect of partial volume effect (PVE) on SUVmax was also assessed. The corrected SUVmax values were obtained based on the recovery coefficient (RC) method. The mean SUVmax for normal vertebrae was 7.08 ± 1.97, 12.59 ± 9.01 for DJD and 36.64 ± 24.84 for bone metastases. The SUVmax of bone metastases was significantly greater than DJD (p value |
| Databáze: | OpenAIRE |
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