Induced pluripotent stem cells from homozygous Runx2-deficient mice show poor response to vitamin D during osteoblastic differentiation

Autor:	Hideto Aoki, Eiichi Suzuki, Takashi Nakamura, Shoko Onodera, Akiko Saito, Manami Ohtaka, Mahito Nakanishi, Ken Nishimura, Atsushi Saito, Toshifumi Azuma
Rok vydání:	2022
Předmět:	Mice Knockout Mice Osteoblasts Induced Pluripotent Stem Cells Animals Osteoporosis Cell Differentiation Core Binding Factor Alpha 1 Subunit General Medicine Vitamin D Cleidocranial Dysplasia Molecular Biology Pathology and Forensic Medicine
Zdroj:	Medical molecular morphology. 55(3)
ISSN:	1860-1499
Popis:	Cleidocranial dysplasia (CCD) is a hereditary disorder associated with skeletal dysplasia and dental abnormalities. CCD arises from heterozygous loss of function mutations in the Runt-related transcription factor 2 (RUNX2) gene. Osteoporosis is often observed in CCD patients and conventional vitamin D supplementation is recommended. However, sufficient evidences have not been presented yet. This study investigated the role of RUNX2 in osteoblastic differentiation and sought to identify potential target genes for the treatment of osteoporosis associated with CCD, using induced pluripotent stem cell (iPSC) technology. We successfully established Runx2
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cb5945bf35cf0dec36a29012ccb86ab https://pubmed.ncbi.nlm.nih.gov/35461467 Zobrazit plný text záznamu Full text from SpringerLink