Self-healing Cutaneous Mucinosis in Adulthood: The Adult Counterpart of the Juvenile Variant of the Disease?
| Autor: | F. Gallardo, Carlos Barranco, Pablo García-Martínez, Gustavo Deza, Ramon M. Pujol |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Mucinoses Biopsy Remission Spontaneous Dermatology Asymptomatic Pathology and Forensic Medicine 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Dermis Fibrosis Humans Medicine Juvenile Skin Wound Healing medicine.diagnostic_test business.industry Mucin Age Factors General Medicine medicine.disease Mucinosis Phenotype medicine.anatomical_structure Female medicine.symptom business Wound healing |
| Zdroj: | The American Journal of Dermatopathology. 41:60-64 |
| ISSN: | 0193-1091 |
| Popis: | Self-healing cutaneous mucinosis (SHCM) is an idiopathic localized cutaneous mucinosis mainly described in children and characterized clinically by an acute onset of papules and nodules that exhibit a spontaneous resolution in a period ranging from weeks to few months. Histologically, a diffuse mucin deposition in the dermis and/or hypodermis associated with a proliferation of spindle-shaped cells and some large epithelioid gangliocyte-like mononuclear cells is usually observed. An uncommon adult variant of SHCM has also been reported; however, the clinicopathological features described in these patients are extremely heterogeneous and differ significantly from the juvenile variant of the disease, often showing exclusively dermal involvement. We report a case of a 37-year-old female patient with multiple asymptomatic nodules located on the legs and arms that resolved spontaneously in a period of 2 years, showing the typical subcutaneous features of the juvenile variant of SHCM at the histological examination (ie, mucinous areas associated with dense bands of fibrosis containing arborizing thin-walled vessels, spindle-shaped fibroblasts, and some gangliocyte-like cells). To the best of our knowledge, this is the first report of SHCM showing the classic pattern of deep-seated subcutaneous involvement of the disease in an adult patient. We also review the cases of adult-onset SHCM reported in the literature. |
| Databáze: | OpenAIRE |
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