Is the routine measurement of ionized calcium worthwhile in patients with cancer?
| Autor: | J. Sanz, Rafael Arjona, R. Valle, Jesús González-Macías, J. R. Barceló, José M. Olmos, Javier Riancho |
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| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty Hypercalcaemia Gastroenterology chemistry.chemical_compound Neoplasms Internal medicine Humans Medicine In patient Prospective Studies Prospective cohort study Aged Calcium metabolism Creatinine Adult patients business.industry digestive oral and skin physiology Albumin Cancer General Medicine Middle Aged Prognosis medicine.disease Surgery chemistry Hypercalcemia Calcium Female business Research Article |
| Zdroj: | Postgraduate Medical Journal. 67:350-353 |
| ISSN: | 1469-0756 0032-5473 |
| DOI: | 10.1136/pgmj.67.786.350 |
| Popis: | Summary This study was undertaken to analyse the relationship between total calcium (TCa) and ionized calcium (ICa) in patients with cancer, and to assess the clinical value of routine measurements of ICa in these patients. Serum TCa, ICa, albumin, proteins and creatinine were measured in 188 adult patients with solid malignant tumours. Most of them were out-patients, the Karnofsky score being 80 or above in 67%. The correlation coefficient between ICa and TCa was 0.85 (P < 0.001) and did not improve after correcting TCa for protein concentration with several published formulae. Although TCa measurements had a global diagnostic accuracy (percent of patients correctly classified) of 90%, they failed to identify a substantial proportion of patients with increased levels of ICa (57% for uncorrected TCa, and 27–57% for protein-corrected TCa). However, the finding of slightly increased ICa levels did not seem to predict the development of frank hypercalcaemia and did not impair the prognosis. According to these results, the routine measurement of ICa in unselected patients with cancer has no clinical usefulness. |
| Databáze: | OpenAIRE |
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