Chronic toxicity of Yellow AB (1-phenylazo-2-naphthylamine) and Yellow OB (1-o-tolylazo-2-naphthylamine)
| Autor: | O. Garth Fitzhugh, W.H. Hansen, Arthur A. Nelson |
|---|---|
| Rok vydání: | 1963 |
| Předmět: |
Pharmacology
medicine.medical_specialty media_common.quotation_subject Spleen Appetite Naphthalenes Toxicology Muscle hypertrophy chemistry.chemical_compound Subcutaneous injection medicine.anatomical_structure Endocrinology chemistry 2-Naphthylamine Internal medicine Ascites medicine Humans Amines Growth inhibition medicine.symptom Azo Compounds Chronic toxicity Carcinogen media_common |
| Zdroj: | Toxicology and Applied Pharmacology. 5:16-35 |
| ISSN: | 0041-008X |
| DOI: | 10.1016/0041-008x(63)90079-6 |
| Popis: | The results of two-year oral toxicity studies with rats at feeding levels of 2500, 1000, and 500 ppm and one-year studies with dogs at 5000, 1000, and 500 ppm for Yellow AB or Yellow OB have been presented. Subcutaneous injection studies with rats and mice also have been reported. Yellow AB and Yellow OB at 2500 ppm of the diet of rats produced high mortality and growth inhibition. Anemia was sometimes present. One or more of subcutaneous edema, hydrothorax, or ascites were seen frequently. In the heart, right-sided hypertrophy, dilatation of the ventricle and atrium, and thrombi were observed. Changes were also observed in the liver, spleen, bone marrow, and testis. Slight but definite effects were caused at the 1000 ppm feeding level, whereas the 500 ppm level produced no demonstrable effects. At 5000 ppm both colors produced marked weight loss and appetite loss in the dogs. One death occurred at the 5000 ppm level of Yellow OB, and another at the 1000 ppm feeding level of Yellow AB. The 1000 ppm level of Yellow OB caused minor effects in 1 of 2 dogs, but 500 ppm of either color was without effect. In limited subcutaneous injection experiments on mice, neither color was carcinogenic. In a two-year experiment on rats with weekly subcutaneous injections of 1.5 mg of color, the results with Yellow AB were considered negative, whereas Yellow OB was considered a mild carcinogen. |
| Databáze: | OpenAIRE |
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