RETRACTED: Mechanism(s) of deep brain stimulation and insights into cognitive outcomes in Parkinson's disease
| Autor: | Vinay Goyal, Shovan Naskar, Madhurima Dhara, Sanjay Sood |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Deep brain stimulation
Movement disorders Parkinson's disease Deep Brain Stimulation Dopamine medicine.medical_treatment Central nervous system disease Cognition Degenerative disease Subthalamic Nucleus Basal ganglia medicine Humans Neurons General Neuroscience Parkinsonism Parkinson Disease medicine.disease nervous system diseases Neostriatum Subthalamic nucleus Treatment Outcome surgical procedures operative nervous system Neurology (clinical) medicine.symptom Psychology therapeutics Neuroscience |
| Zdroj: | Brain Research Reviews. 65:1-13 |
| ISSN: | 0165-0173 |
| Popis: | Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor, cognitive, neuropsychiatric, autonomic, and other nonmotor symptoms. Deep brain stimulation (DBS) at high frequency is now considered the most effective neurosurgical therapy for movement disorders, especially PD. An electrode is chronically implanted in a particular area of the brain and, when continuously stimulated, it significantly alleviates motor symptoms. In Parkinson's disease, the common target nuclei of high frequency stimulation (HFS) are the basal ganglia nuclei, such as the internal segment of the pallidum and the subthalamic nucleus (STN), with a preference for the STN in recent years. Two fundamental mechanisms have been proposed to underlie the beneficial effects of HFS: either silencing or excitation of STN neurons. This article highlights the recent views concerned with the mechanisms of DBS. Although the efficacy of DBS for the motor symptoms of advanced PD is well established, the effects of DBS on the cognitive and neuropsychiatric symptoms are less clear. The cognitive aspects of DBS for PD have recently been of considerable clinical and pathophysiological interest. This article also reviews the published literature on the cognitive aspects of DBS for PD. |
| Databáze: | OpenAIRE |
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