Perineural invasion by transitional cell carcinoma of the bladder in patients submitted to radical cystectomy: what is the prognostic value?
| Autor: | Luciano J. Nesrallah, Mario Paranhos, Alexandre Crippa, Alberto A. Antunes, Katia R. M. Leite, Marcos F. Dall'Oglio, Adriano Nesrallah, Miguel Srougi |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Urology medicine.medical_treatment bladder neoplasms Perineural invasion carcinoma lcsh:RC870-923 Disease-Free Survival Cystectomy symbols.namesake cystectomy Risk Factors Bladder Neoplasm Peripheral Nervous System medicine Carcinoma Humans Neoplasm Invasiveness Survival analysis Fisher's exact test Aged Neoplasm Staging Retrospective Studies Aged 80 and over Carcinoma Transitional Cell business.industry Proportional hazards model Middle Aged lcsh:Diseases of the genitourinary system. Urology medicine.disease Surgery Transitional cell carcinoma Urinary Bladder Neoplasms transitional cell symbols Female prognosis business |
| Zdroj: | International braz j urol, Volume: 33, Issue: 2, Pages: 161-166, Published: APR 2007 International Brazilian Journal of Urology, Vol 33, Iss 2, Pp 161-166 (2007) International braz j urol v.33 n.2 2007 International Braz J Urol Sociedade Brasileira de Urologia (SBU) instacron:SBU |
| ISSN: | 1677-5538 |
| Popis: | OBJECTIVE: Determine the prognostic value of perineural invasion (PNI) in patients with transitional cell carcinoma (TCC) of the bladder treated with radical cystectomy. MATERIALS AND METHODS: From January 1993 to January 2005, 113 people were selected from 153 patients with TCC of the bladder treated with radical cystectomy. The association between the presence of PNI and other pathologic characteristics were analyzed through Fisher exact test. The Kaplan-Meier method was utilized to assess the survival curve and the statistical significance was determined by the Breslow test. The multivariate analysis was performed through the Cox regression model. RESULTS: The PNI was identified in 10 (8.8%) of the 113 patients. This variable significantly related to the microvascular invasion and to tumor staging. The mean segment after surgery was 31.7 ± 28.5 months. Recurrence occurred in 5 (50%) and in 41 (39.8%) patients (p = 0.363) and mortality occurred in 2 (20%) and 22 (21.9%) patients (p = 0.606) with or without PNI respectively. In Cox regression analysis, patients with PNI presented with 1.53 times (IC 95% 0.60 to 3.91; p = 0.371) and 1.60 times (IC 95% 0.37 to 6.95; p = 0.532) the risk of recurrence and mortality when compared to patients without PNI. CONCLUSIONS: The PNI does not constitute an independent variable of disease-free and cancer specific survival in patients with TCC of the bladder treated with radical cystectomy. |
| Databáze: | OpenAIRE |
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