Racial Health Disparities, and Variant Red Cell and Iron Homeostasis
| Autor: | Galina Shamayeva, Bruce K. Chow, Leo R. Zacharski, Ralph G. DePalma |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Iron Black People 030204 cardiovascular system & hematology medicine.disease_cause White People 03 medical and health sciences 0302 clinical medicine Iron homeostasis Internal medicine Medicine Homeostasis Humans 030212 general & internal medicine chemistry.chemical_classification biology Red Cell business.industry Transferrin saturation Public Health Environmental and Occupational Health Transferrin Health Status Disparities Health equity Ferritin Endocrinology chemistry Immunology Ferritins biology.protein Hemoglobin business Oxidative stress |
| Zdroj: | Journal of health care for the poor and underserved. 27(2) |
| ISSN: | 1548-6869 |
| Popis: | Oxidative stress from excess iron may contribute to racial health disparities. Previously we reported improved clinical outcomes with lower ferritin and higher percent transferrin saturation (%TS) levels in White but not Black participants with peripheral arterial disease entered to a clinical trial. This report demonstrates racially variant interactions between hemoglobin, ferritin, and %TS levels. Lower hemoglobin and %TS levels, and higher ferritin levels were documented in Black compared with White participants within cardiovascular disease risk categories. Ferritin levels near 80 ng/mL related to higher hemoglobin levels in White but not Black participants. Higher %TS levels with ferritin levels above 80 ng/mL in White participants were blunted in Black participants. Ferritin/%TS ratios were significantly higher in Black than White participants. Iron incorporation into hemoglobin and scavenging by transferrin may buffer iron toxicity more effectively in White than in Black individuals. Metabolic vulnerability to iron excess may explain, in part, racial health disparities. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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