Accumulation of CD28null Senescent T-Cells Is Associated with Poorer Outcomes in COVID19 Patients

Autor:	Kourtney M. Zimmerly, Xuexian O. Yang, Mia J. Coleman
Rok vydání:	2021
Předmět:	Senescence CD28null T-cells COPD senescence business.industry Mortality rate COVID-19 Cancer Disease medicine.disease Microbiology Biochemistry Asymptomatic QR1-502 inflammation Infectious disease (medical specialty) Diabetes mellitus Immunology medicine cytotoxicity medicine.symptom business immune decline Molecular Biology
Zdroj:	Biomolecules, Vol 11, Iss 1425, p 1425 (2021)
ISSN:	2218-273X
DOI:	10.3390/biom11101425
Popis:	Coronavirus disease 2019 (COVID-19), a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes infectious disease, and manifests in a wide range of symptoms from asymptomatic to severe illness and even death. Severity of infection is related to many risk factors, including aging and an array of underlying conditions, such as diabetes, hypertension, chronic obstructive pulmonary disease (COPD), and cancer. It remains poorly understood how these conditions influence the severity of COVID-19. Expansion of the CD28null senescent T-cell populations, a common phenomenon in aging and several chronic inflammatory conditions, is associated with higher morbidity and mortality rates in COVID-19. Here, we summarize the potential mechanisms whereby CD28null cells drive adverse outcomes in disease and predispose patients to devastating COVID-19, and discuss possible treatments for individuals with high counts of CD28null senescent T-cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bd759f80c9acd7989a64042078e0499 https://doi.org/10.3390/biom11101425 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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