IMMUNOGLOBULINS AND ALBUMIN IN SPUTUM FROM PATIENTS WITH CYSTIC FIBROSIS
| Autor: | Niels Høiby, P. O. Schiøtz, I Clemmensen |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Immunoglobulin A Proteases Adolescent Cystic Fibrosis Immunoglobulins Fibrinogen Cystic fibrosis Immunoglobulin G Microbiology Fibrin Fibrinogen Degradation Products fluids and secretions Albumins medicine Humans Child Glycoproteins biology Sputum Albumin Proteins General Medicine medicine.disease Precipitin respiratory tract diseases Immunoglobulin A Secretory Chromatography Gel biology.protein Female medicine.symptom Peptide Hydrolases medicine.drug |
| Zdroj: | Acta Pathologica Microbiologica Scandinavica Section C Immunology. :275-280 |
| ISSN: | 0304-1328 |
| DOI: | 10.1111/j.1699-0463.1980.tb00106.x |
| Popis: | Sputum sol phase from seventeen cystic fibrosis (CF) patients chronically infected in the lungs with mucoid Pseudomonas aeruginosa and presenting multiple precipitins in serum against this bacterium (CF + P) and 11 CF patients without P. aeruginosa infection (CF-P) were examined for proteolytic activity in a fibrin plate assay. The proteolytic activity was significantly higher (p smaller than 0.02) in sputum from CF + P patients than in sputum from CF-patients. This difference was only quantitative since sputum sol phase from both groups degraded fibrinogen to non-precipitable material. The proteolytic degradation of IgG, IgA, secretory IgA and albumin in the sputum sol phases was investigated by means of gel filtration and the stability of these proteins during various storage conditions was examined. Degradation of IgG, IgA, secretory IgA and albumin in the sputa was not demonstrable and the proteins were stable for at least 4 weeks at 4 degree C. |
| Databáze: | OpenAIRE |
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