Elevated High-Sensitivity C-Reactive Protein Levels Predict Decreased Survival for Nasopharyngeal Carcinoma Patients in the Intensity-Modulated Radiotherapy Era
| Autor: | Hai Qiang Mai, Xiao Ping Lai, Lin Quan Tang, Mu Sheng Zeng, Wen Hui Chen, Lu Zhang, Xiang Guo, Yun Xiu Xiu Xu, Yun He, Shi Hua Wen, Chao Nan Qian, Qiu Yan Chen, Yu Tuan Peng, Dong Peng Hu, Li Ting Liu, Shan Shan Guo |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Nasopharyngeal neoplasm lcsh:Medicine Kaplan-Meier Estimate Gastroenterology Disease-Free Survival Risk Factors Diabetes mellitus Internal medicine Blood plasma medicine Humans Progression-free survival lcsh:Science Survival rate Aged Neoplasm Staging Nasopharyngeal Carcinoma Multidisciplinary biology business.industry Carcinoma lcsh:R C-reactive protein Nasopharyngeal Neoplasms Middle Aged Prognosis medicine.disease C-Reactive Protein Nasopharyngeal carcinoma Immunology biology.protein Female lcsh:Q Radiotherapy Intensity-Modulated Cisplatin business Body mass index Research Article |
| Zdroj: | PLoS ONE, Vol 10, Iss 4, p e0122965 (2015) PLoS ONE |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0122965 |
| Popis: | Purpose This study aimed to clarify the prognostic utility of high-sensitivity C-reactive protein (hs-CRP) in nasopharyngeal carcinoma (NPC) patients in the Intensity-Modulated Radiotherapy (IMRT) era. Patients and Methods In this observational study, 1,589 non-metastatic NPC patients treated with IMRT were recruited. Blood samples were collected before treatment for examination of hs-CRP levels. We evaluated the association of pretreatment hs-CRP levels with overall survival rate (OS), progression free survival rate (PFS), locoregional relapse free survival rate (LRFS) and distant metastasis free survival rate (DMFS). Results Baseline hs-CRP levels were correlated with sex, clinical stage, body mass index, smoking status, and EBV DNA level. Multivariate analysis showed that hs-CRP had significant association with OS (HR:1.723; 95%CI:1.238–2.398; p = 0.001), PFS (HR:1.621; 95%CI:1.273–2.064; p |
| Databáze: | OpenAIRE |
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