Cerebrospinal fluid type I interferon and cytokine profiles in enteroviral meningitis according to the presence or absence of pleocytosis
| Autor: | Won Hyeok Lee, Jae Hee Seol, Kyung Yeon Lee, Chae Hyeon Yi |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
pleocytosis medicine.medical_specialty Leukocytosis medicine.medical_treatment Pediatrics Polymerase Chain Reaction Gastroenterology cerebrospinal fluid RJ1-570 03 medical and health sciences 0302 clinical medicine Cerebrospinal fluid Interferon 030225 pediatrics Internal medicine Enterovirus Infections Viral meningitis medicine Humans interferon-beta Child Pleocytosis Interleukin 6 biology business.industry Significant difference enteroviral meningitis Infant medicine.disease Meningitis Viral Enteroviral meningitis 030104 developmental biology Cytokine Interferon Type I Pediatrics Perinatology and Child Health biology.protein Cytokines business medicine.drug |
| Zdroj: | Pediatrics and Neonatology, Vol 62, Iss 3, Pp 305-311 (2021) |
| ISSN: | 1875-9572 |
| Popis: | Background: Enteroviral meningitis is typically diagnosed as the presence of pleocytosis and of viral RNA in cerebrospinal fluid. However, it was recently reported that more than 50% of infants with enteroviral meningitis diagnosed by polymerase chain reaction had no cerebrospinal fluid pleocytosis. This study investigated type I interferon (IFN) and cytokine profiles in the cerebrospinal fluid based on the presence or absence of cerebrospinal fluid pleocytosis in children with enteroviral meningitis. Methods: We included 51 enteroviral meningitis patients showing cerebrospinal fluid pleocytosis (pleocytosis group), 31 enteroviral meningitis patients without cerebrospinal fluid pleocytosis (non-pleocytosis group), and 52 controls (control group) and compared cerebrospinal fluid interleukin 6 (IL-6), IL-8, chemokine (C-X-C motif) ligand 10 (CXCL-10), IFN-α, and IFN-β levels. Results: A significant difference was observed in IL-6, IL-8, and CXCL-10 levels across the three groups, with highest values in the pleocytosis patients, followed by those in the non-pleocytosis and control subjects. IFN-α level was higher in the pleocytosis group than in the non-pleocytosis and control groups. Meanwhile, the IFN-β level was higher in the pleocytosis and non-pleocytosis groups than in the control group (34.54 [31.23–38.59] pg/mL vs. 33.21 [31.23–35.21] pg/mL vs. 0.00 [0.00–0.00] pg/mL, respectively; P |
| Databáze: | OpenAIRE |
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