Ultrastructural changes in Raillietina (Platyhelminthes: cestoda), exposed to sulfonoquinovosyldiacylglyceride (SQDG), isolated from Neem (Azadirachta indica)
| Autor: | Yogesh P. Bharitkar, Nirup B. Mondal, Pradip Kumar Kar, Sanatan Murmu, Anirban Ash, V. Ravichandiran, Abhijit Hazra |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Death time Cestoda Plant Science Biochemistry Analytical Chemistry 03 medical and health sciences Glycolipid Raillietina Botany medicine Animals Anthelmintic Anthelmintics Azadirachta biology Traditional medicine Organic Chemistry 030108 mycology & parasitology biology.organism_classification Plant Leaves 030104 developmental biology Ultrastructure Glycolipids Chickens medicine.drug |
| DOI: | 10.6084/m9.figshare.4793356.v1 |
| Popis: | Neem (Azadirachta indica), has been known to be a curative for various ailments and diseases in the traditional Indian medicinal system from times immemorial. A glycolipid sulfonoquinovosyldiacylglyceride (SQDG) isolated from the leaves of neem has been found to be a proactive antibacterial and antiviral agent in previous studies. The current communication pertains to the anthelmintic activity of SQDG in vitro against a model cestode Raillietina spp. The results of efficacy tests showed a paralysis time of 1.0 ± 0.1 and 0.7 ± 0.01 h, whereas death time of 1.6 ± 0.3 and 0.9 ± 0.02 h, following treatments with dosages of 0.5 and 1.0 mg/mL, respectively. The scanning electron microscopic studies showed significant and unique changes in the ultrastructure of the worms with prominent breakages and furrows on the surface. |
| Databáze: | OpenAIRE |
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