Thyroid Function in Kuwaiti Subjects with Down’s Syndrome
| Autor: | Waleed A. Al-Busairi, Hossam A. Bayoumy, Abdul Naser A. Al-Othman, Abdul Salam R. Mohammad, Fawzi E. Ali |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Wolff–Chaikoff effect Adolescent endocrine system diseases Thyroid Gland Thyrotropin Enzyme-Linked Immunosorbent Assay Thyroid Function Tests Hyperthyroidism Rehabilitation Centers Thyroid function tests Residential Facilities Hypothyroidism Internal medicine Prevalence medicine Humans S syndrome biology medicine.diagnostic_test business.industry Thyroid General Medicine eye diseases Anti-thyroid autoantibodies Thyroxine medicine.anatomical_structure Endocrinology Kuwait biology.protein Female Down Syndrome Antibody Thyroid function business Biomarkers |
| Zdroj: | Medical Principles and Practice. 11:206-209 |
| ISSN: | 1423-0151 1011-7571 |
| DOI: | 10.1159/000065807 |
| Popis: | Objective: To investigate the thyroid function of individuals with Down’s syndrome (DS). Methods: Thyroid function and antithyroid antibodies were measured in 58 Kuwaitis with DS who resided at a residential facility or attended rehabilitation centers. Results: Twenty-six subjects (45%) were euthyroid and 32 (55%) had thyroid dysfunction. One patient had previously been diagnosed with thyroid failure whereas the other 31 patients had newly discovered disease: 9 patients had primary hypothyroidism (T4 9.95 ± 1.1 pmol/l and TSH 15.15 ± 11.93 mU/l), 19 subclinical hypothyroidism (TSH 6.47 ± 2.57 mU/l), 1 secondary hypothyroidism, 1 hyperthyroidism, and the remaining 1 subclinical hyperthyroidism. Antithyroid antibodies were found in 52% of the total subjects and in 59% of those with thyroid dysfunction. Conclusions: Thyroid dysfunction is common in Kuwaiti subjects with DS and is presumably the consequence of autoimmune thyroid disease. Periodic thyroid function testing is recommended in individuals with DS, which is best done through a national program. |
| Databáze: | OpenAIRE |
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