Socioeconomic disparities of depressive symptoms and cytokines in hepatocellular carcinoma

Autor:	Thomas W. Kamarck, James W. Marsh, Peter J. Gianaros, Allan Tsung, Jennifer L. Steel, Yanet Vanegas, David A. Geller, Kathryn A. Roecklein, Hannah Cheng, Nadia S. Ahmed
Rok vydání:	2019
Předmět:	Adult Male medicine.medical_specialty Carcinoma Hepatocellular Psychological intervention Experimental and Cognitive Psychology Article 03 medical and health sciences symbols.namesake 0302 clinical medicine Internal medicine Humans Medicine In patient 030212 general & internal medicine Socioeconomic status Depressive symptoms Depression (differential diagnoses) Aged Aged 80 and over Inflammation Depression business.industry Liver Neoplasms Cancer Middle Aged medicine.disease Psychiatry and Mental health Bonferroni correction Socioeconomic Factors Oncology 030220 oncology & carcinogenesis Hepatocellular carcinoma symbols Cytokines Female business
Zdroj:	Psychooncology
ISSN:	1099-1611 1057-9249
DOI:	10.1002/pon.5127
Popis:	Objective To examine the associations among socioeconomic factors, depressive symptoms, and cytokines in patients diagnosed with hepatocellular carcinoma (HCC). Methods A total of 266 patients diagnosed with HCC were administered a battery of questionnaires including a sociodemographic questionnaire and the Center for Epidemiologic StudiesDepression (CES-D) scale. Blood samples were collected to assess serum levels of cytokines using Luminex. Descriptive statistics, Mann-Whitney U, Kruskal-Wallis, linear regression, and Bonferroni corrections were performed to test the hypotheses. Results Of the 266 patients, 24% reported depressive symptoms in the clinical range (CES-D ≥ 22). Females had higher CES-D score than males (Mann-Whitney U = 7135, P = .014, Padj = .028). Being unemployed/disabled (Kruskal-Wallis = 14.732, P = .001, Padj = .005) was found to be associated with higher depressive symptoms in males but not in females. Serum level of IL-2 (Kruskal-Wallis = 17.261, P = .001, Padj = .005) were found to be negatively associated with education level. Gender (β = .177, P = .035), income (β = -.252, P = .004), whether the patient's income met their basic needs (β = .180, P = .035), and IL-1β (β = -.165, P = .045) independently predicted depressive symptoms and together explained 19.4% of variance associated with depressive symptoms. Conclusions Sociodemographic and socioeconomic factors were predictive of inflammation and depressive symptoms. Recommendations include the development of gender-targeted interventions for patients diagnosed with HCC who have low socioeconomic status (SES) and may suffer from depressive symptoms.
Databáze:	OpenAIRE
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