Sympathectomy or Doxazosin, But Not Propranolol, Blunt Myocardial Interstitial Fibrosis in Pressure-Overload Hypertrophy
| Autor: | Alberto U. Ferrari, Roberto Fogari, Francesca Clari, Giuseppina Palladini, Rossana Tozzi, Giuseppe Busca, Silvia Fallarini, Rosanna Nano, Stefano Perlini, Ivana Ferrero, Angelica Facoetti |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Adrenergic beta-Antagonists Blood Pressure Cardiomegaly Propranolol Muscle hypertrophy Rats Sprague-Dawley Fibrosis Internal medicine Internal Medicine Doxazosin Animals Medicine Lung Adrenergic alpha-Antagonists Pressure overload Tissue Inhibitor of Metalloproteinase-2 business.industry Myocardium Sympathectomy Chemical medicine.disease Rats Endocrinology Blood pressure Sympathectomy Heart failure Hypertension Matrix Metalloproteinase 2 Collagen business medicine.drug |
| Zdroj: | Hypertension. 46:1213-1218 |
| ISSN: | 1524-4563 0194-911X |
| DOI: | 10.1161/01.hyp.0000185689.65045.4c |
| Popis: | The adaptive changes that develop in the pressure-overloaded left ventricular (LV) myocardium include cardiomyocyte hypertrophy and interstitial fibrosis. Although the former is known to depend to a sizeable extent on sympathetic (over)activity, little information exists whether the same applies to the latter, ie, whether excess catecholamine exposure contributes to the imbalance between collagen deposition by fibroblasts and degradation by matrix metalloproteases (MMPs), eventually leading to LV collagen accumulation. Sprague-Dawley rats were subjected to abdominal aortic banding (B) or sham operation (S) and treated with β-blockade (Bb, oral propranolol, 40 mg/kg per day), chemical sympathectomy (Sx, 6-hydroxydopamine, 150 mg/kg intraperitoneal twice per week) or vehicle (Vh). Ten weeks later, systolic blood pressure, LV weight, collagen abundance (computer-aided histology), zymographic matrix metalloproteinase (MMP)-2 activity and its specific tissue inhibitor concentration (TIMP-2) were measured. Both sympathectomy and β-blockade failed to attenuate the banding-induced blood pressure elevation but significantly attenuated the attendant LV hypertrophy. As expected, pressure-overload hypertrophy was associated with interstitial fibrosis (collagen: 4.37±1.23% BVh versus 1.23±0.44% SVh, P P =not significant versus SSx) but left unchanged by β-blockade (4.11±1.23%, P P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|