Green microfluidic liquid-phase microextraction of polar and non-polar acids from urine
| Autor: | Elia Santigosa, Stig Pedersen-Bjergaard, María Ramos-Payán, Maria Muñoz |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Analyte Naproxen Liquid Phase Microextraction 02 engineering and technology 01 natural sciences Biochemistry Analytical Chemistry chemistry.chemical_compound Lab-On-A-Chip Devices Anthranilic acid medicine Humans Eutectic system Aqueous solution Chromatography 010401 analytical chemistry Extraction (chemistry) Hippuric acid Equipment Design 021001 nanoscience & nanotechnology 0104 chemical sciences Membrane chemistry Solvents Female 0210 nano-technology Acids medicine.drug |
| Zdroj: | Analytical and bioanalytical chemistry. 413(14) |
| ISSN: | 1618-2650 |
| Popis: | In this work, hippuric acid (log P = 0.5), anthranilic acid (log P = 1.3), ketoprofen (log P = 3.6), and naproxen (log P = 3.0) were simultaneously extracted by a green microfluidic device based on the principles of liquid-phase microextraction (LPME). Different deep eutectic solvents (DESs) were investigated as supported liquid membrane (SLM), and a mixture of camphor and menthol as eutectic solvents in the molar ratio 1:1 was found to be highly efficient for the simultaneous extraction of non-polar and polar acidic drugs. LPME was conducted for 6 min per sample. Urine sample was delivered to the system at 1 μL min−1, and target analytes were extracted exhaustively (75–100% recovery) across the DES SLM, and into pure aqueous phosphate buffer pH 11.0 delivered as acceptor at 1 μL min−1. The acceptor was analyzed with liquid chromatography-UV detection. Interestingly, the DES enabled extraction of both the polar and non-polar model analytes at the same time; all chemicals were green and non-hazardous, and the chemical waste was less than 1 mg per sample. |
| Databáze: | OpenAIRE |
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