The Increased Expression of Toll-Like Receptor 4 in Renal and Skin Lesions in Lupus Erythematosus
| Autor: | Mariem Ben Jmaa, O. Abida, Tahya Sellami, Lobna Ayadi, Nesrine Elloumi, Raouia Fakhfakh, Khadija Sellami, Khawla Kammoun, Hatem Masmoudi |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine Pathology medicine.medical_specialty Histology Adolescent Lupus nephritis Biology Kidney Pathogenesis Young Adult 03 medical and health sciences Lupus Erythematosus Discoid 0302 clinical medicine Immune system Dermis medicine Humans Aged Skin Toll-like receptor Lupus erythematosus Epidermis (botany) Articles Middle Aged medicine.disease Immunohistochemistry Lupus Nephritis Toll-Like Receptor 4 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Immunology Female Anatomy |
| Zdroj: | Journal of Histochemistry & Cytochemistry. 65:389-398 |
| ISSN: | 1551-5044 0022-1554 |
| DOI: | 10.1369/0022155417709234 |
| Popis: | Toll-like receptor 4 (TLR-4), a bacterial lipopolysaccharide sensor, is an innate immunity essential modulator. It is expressed on both immune and non-immune cells and may contribute to the cutaneous and renal manifestations during lupus erythematosus (LE). Our purpose is to evaluate TLR-4 expression and analyzing its role in lupus nephritis (LN) and chronic cutaneous lupus erythematosus (CLE) pathogenesis. TLR-4 immunohistochemical staining was performed on 30 LN renal biopsies compared with 11 healthy renal tissues and 30 skin biopsies from CLE patients compared with 15 normal individuals. CLE patients’ biopsies showed a strong and diffuse TLR-4 expression throughout the epidermis and labeled inflammatory infiltrate and glands in the dermis whereas controls’ skin expressed weakly TLR-4 only in the epidermis basal layer. LN glomeruli and tubules showed an increased and more intense TLR-4 expression compared with normal controls where TLR-4 expression was weak and rarely detected in glomeruli, diffuse and weak in tubules. A significant difference in TLR-4 expression between LN classes, both in glomeruli and tubules, was observed. These data confirm an up-regulation of TLR-4 expression in the affected tissues of CLE and LN patients and highlight the critical role of TLR-4 in the pathogenesis of cutaneous and renal disorders in LE. |
| Databáze: | OpenAIRE |
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