Synthesis of griseolic acid B by pi-face-dependent radical cyclization
| Autor: | Thomas J. Emge, George A. Doss, Gregori J. Morriello, Zhijian Lu, Machender R. Madduru, Spencer Knapp |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adenosine
Magnetic Resonance Spectroscopy Bicyclic molecule Chemistry Phosphodiesterase Inhibitors Organic Chemistry Stereoisomerism Vinyl ether Biochemistry Medicinal chemistry Radical cyclization Streptomyces 3' 5'-Cyclic-AMP Phosphodiesterases Cyclization medicine Indicators and Reagents Physical and Theoretical Chemistry Griseolic acid B Oxidation-Reduction medicine.drug |
| Zdroj: | Organic letters. 3(22) |
| ISSN: | 1523-7060 |
| Popis: | [reaction: see text]. Radical cyclization of 6 affords the bicyclic vinyl ether 9 with the appropriate stereochemistry for elaboration (seven steps) to griseolic acid B (1). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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