Systems Genomics of Metabolic Phenotypes in Wild-Type Drosophila melanogaster
| Autor: | Lubna Rashid, Benjamin Hsieh, Nigel Deighton, Norm Glassbrook, Greg Gibson, Zhi Zhang, Rolf Bodmer, Laura K. Reed, Amy Poe, Kevin Lee |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Genome Insect Genomics adaptation Investigations metabolic syndrome Transcriptome 03 medical and health sciences evolve-and-resequence 0302 clinical medicine Metabolomics Genome and Systems Biology Gene Frequency Genotype Genetics Metabolome Animals Selection Genetic Allele frequency 030304 developmental biology 2. Zero hunger 0303 health sciences genotype-by-environment biology Systems Biology biology.organism_classification Phenotype metabolomics Adaptation Physiological Diet Drosophila melanogaster Female 030217 neurology & neurosurgery |
| Zdroj: | Genetics |
| ISSN: | 1943-2631 0016-6731 |
| Popis: | Systems biology is an approach to dissection of complex traits that explicitly recognizes the impact of genetic, physiological, and environmental interactions in the generation of phenotypic variation. We describe comprehensive transcriptional and metabolic profiling in Drosophila melanogaster across four diets, finding little overlap in modular architecture. Genotype and genotype-by-diet interactions are a major component of transcriptional variation (24 and 5.3% of the total variation, respectively) while there were no main effects of diet ( |
| Databáze: | OpenAIRE |
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