Characterization of biodegradable polymers with capacitive field-effect sensors
| Autor: | Matthias Bäcker, M. Leinhos, Michael J. Schöning, Patrick Wagner, Sebastian Schusser, Arshak Poghossian |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
chemistry.chemical_classification
Materials science Capacitive sensing Metals and Alloys Field effect Field-effect sensor Impedance spectroscopy Nanotechnology Polymer Real-time monitoring Condensed Matter Physics Capacitance Biodegradable polymer Surfaces Coatings and Films Electronic Optical and Magnetic Materials Dielectric spectroscopy Characterization (materials science) chemistry C-V method Materials Chemistry Degradation (geology) Poly(D L-lacticacid) Electrical and Electronic Engineering Instrumentation (Bio)degradation |
| Popis: | In vitro studies of the degradation kinetic of biopolymers are essential for the design and optimization of implantable biomedical devices. In the presented work, a field-effect capacitive sensor has been applied for the real-time and in situ monitoring of degradation processes of biopolymers for the first time. The polymer-covered field-effect sensor is, in principle, capable to detect any changes in bulk, surface and interface properties of the polymer induced by degradation processes. The feasibility of this approach has been experimentally proven by using the commercially available biomedical polymer poly(d, l-lactic acid) (PDLLA) as a model system. PDLLA films of different thicknesses were deposited on the Ta2O5 gate surface of the field-effect structure from a polymer solution by means of spin-coating method. The polymer-modified field-effect sensors have been characterized by means of capacitance-voltage and impedance-spectroscopy method. The degradation of the PDLLA was accelerated by changing the degradation medium from neutral (pH 7.2) to alkaline (pH 9) condition, resulting in drastic changes in the capacitance and impedance spectra of the polymer-modified field-effect sensor. © 2012 Elsevier B.V. All rights reserved. ispartof: Sensors and Actuators B, Chemical vol:187 pages:2-7 status: published |
| Databáze: | OpenAIRE |
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