Phenytoin Administration to Pregnant Mice: a Mutagenic Action?
| Autor: | Claude Petter, Maud Ehrensperger, Marie-Noelle Lombard |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Phenytoin
Necrosis Offspring business.industry Abnormalities Drug-Induced Physiology Fetal Resorption Mice stomatognathic diseases Fertility Pregnancy Nmri mice Anesthesia Pediatrics Perinatology and Child Health medicine Animals Female Mating medicine.symptom business Mutagens Developmental Biology medicine.drug |
| Zdroj: | Neonatology. 39:246-252 |
| ISSN: | 1661-7819 1661-7800 |
| DOI: | 10.1159/000241444 |
| Popis: | Phenytoin orally administered to pregnant NMRI mice results in limb haemorrhages, necrosis, and in most cases in limb amputations in the offspring. By mating these offspring without any treatment, the same type of abnormalities appeared throughout seven successive generations. In the second and third generations, other malformations, such as haemorrhages of the eyelids, and genitourinary defects were observed. These findings raise the question of the mutagenic role of phenytoin. Phenytoin is a drug of considerable medical use, but very little is known about the various possible intermediate steps involved in its action. |
| Databáze: | OpenAIRE |
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