Opportunistic detection of atrial fibrillation in subjects aged 65 years or older in primare care: a randomised clinical trial of efficacy. DOFA-AP study protocol
| Autor: | Antonio Valero-Martín, Margarita Criado-Larumbe, Carlos Pérula-de-Torres, Roger Ruiz-Moral, Mercè Cervera-León, Juan Manuel Parras-Rejano, José M Baena-Díez, Ana Roldán-Villalobos, Lluís Cuixart-Costa, Joaquin Ruiz-de-Castroviejo, Remedios Martín-Álvarez, Miguel Á Martínez-Adell, Virginia González-Blanco, Modesto Pérez-Díaz, Enrique Martín-Rioboó, Jose Angel Fernández-García, Emili Burdoy-Joaquín, Luis Ángel Pérula-de-Torres, Jesús González-Lama, Montserrat Coma-Solé |
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| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Multivariate analysis Randomization Opportunistic case finding law.invention Study Protocol Randomized controlled trial law medicine Humans Mass Screening Pulse Mass screening Aged Protocol (science) lcsh:R5-920 Primary Health Care business.industry Secondary prevention Atrial fibrillation Primary care medicine.disease Stratified sampling Clinical trial Logistic Models Spain Multivariate Analysis Screening Physical therapy lcsh:Medicine (General) Family Practice business |
| Zdroj: | BMC Family Practice DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria instname BMC Family Practice, Vol 13, Iss 1, p 106 (2012) DDFV: Repositorio Institucional de la Universidad Francisco de Vitoria Universidad Francisco de Vitoria |
| ISSN: | 1471-2296 |
| DOI: | 10.1186/1471-2296-13-106 |
| Popis: | Background Clinical Practice Guidelines recommend using peripheral blood pulse measuring as a screening test for Atrial Fibrillation. However, there is no adequate evidence supporting the efficacy of such procedure in primary care clinical practice. This paper describes a study protocol designed to verify whether early opportunistic screening for Atrial Fibrillation by measuring blood pulse is more effective than regular practice in subjects aged 65 years attending primary care centers. Methods/design An cluster-randomized controlled trial conducted in Primary Care Centers of the Spanish National Health Service. A total of 269 physicians and nurses will be allocated to one of the two arms of the trial by stratified randomization with a 3:2 ratio (three practitioners will be assigned to the Control Group for every two practitioners assigned to the Experimental Group). As many as 12 870 patients aged 65 years or older and meeting eligibility criteria will be recruited (8 580 will be allocated to the Experimental Group and 4 290 to the Control Group). Randomization and allocation to trial groups will be carried out by a central computer system. The Experimental Group practitioners will conduct an opportunistic case finding for patients with Atrial Fibrillation, while the Control Group practitioners will follow the regular guidelines. The first step will be finding new Atrial Fibrillation cases. A descriptive inferential analysis will be performed (bivariate and multivariate by multilevel logistic regression analysis). Discussion If our hypothesis is confirmed, we expect Primary Care professionals to take a more proactive approach and adopt a new protocol when a patient meeting the established screening criteria is identified. Finally, we expect this measure to be incorporated into Clinical Practice Guidelines. Trial registration The study is registered as NCT01291953 (ClinicalTrials.gob) |
| Databáze: | OpenAIRE |
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