Hemostasis parameters during ovarian stimulation for in vitro fertilization: results of a prospective study
| Autor: | Patricia Aguilar-Martinez, Isabelle Bernard, Herisoa Rabesandratana, Florence Galtier-Dereure, Bernard Hedon, Jean-François Schved, C. Biron |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
medicine.medical_specialty media_common.quotation_subject medicine.medical_treatment Fertilization in Vitro Thromboplastin Ovarian Hyperstimulation Syndrome Sex hormone-binding globulin Obstetrics and gynaecology Medicine Humans Prospective Studies Prospective cohort study Ovulation Menstrual cycle media_common Respiratory Burst Gynecology Hemostasis In vitro fertilisation biology Estradiol business.industry Vascular disease Obstetrics and Gynecology medicine.disease Reproductive Medicine Anesthesia biology.protein Female business |
| Zdroj: | Fertility and sterility. 67(1) |
| ISSN: | 0015-0282 |
| Popis: | Objective: To evaluate the effect of IVF-ET on the hemostatic system. Design: Prospective clinical study. Setting: Apparently healthy age-matched women of the hospital staff at various stage of the menstrual cycle. Patient(s): Twenty-five women involved in a IVF-ET program at the Department of Obstetrics and Gynecology, Montpellier University Hospital. Intervention(s): Twenty-six hemostasis parameters evaluated repeatedly in patients undergoing IVF-ET. Main Outcome Measure(s): Blood cell-dependent hemostasis parameters and plasmatic coagulation factors, determined at pituitary desensitization, maximal E 2 level, and P plateau. Result(s): Activation of the hemostatic system is evidenced at the P plateau, when D-dimers and fragments 1 + 2 of the prothrombin levels rose dramatically. At E 2 peak, no significant modification of hemostasis markers was noted. Conclusion(s): The present results indicate that ovarian hyperstimulation may induce hemostasis activation at the P plateau. The role of supraphysiologic sex hormone levels on the hemostatic system requires further investigation. |
| Databáze: | OpenAIRE |
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