Cervical ripening in the third trimester of pregnancy with intravaginal misoprostol: a double-blind, randomized, placebo-controlled study
| Autor: | Li Weiji, Su Xiaowen, Ding Yulian, Wang Feng, Ouyang Weixiang, Wang Zehua, Xu Liuqing |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
medicine.medical_specialty Pregnancy Trimester Third Placebo-controlled study Bishop score Placebo Double-Blind Method Pregnancy Management of Technology and Innovation medicine.artery Oxytocics Fetal distress medicine Humans Labor Induced Misoprostol Cervix Obstetrics business.industry Umbilical artery medicine.disease Administration Intravaginal medicine.anatomical_structure Female business medicine.drug Cervical Ripening |
| Zdroj: | Journal of Tongji Medical University = Tong ji yi ke da xue xue bao. 18(3) |
| ISSN: | 0257-716X |
| Popis: | To evaluate the safety and efficacy of intravaginal misoprostol for cervical ripening in the third trimester, a randomized, double-blind, placebo-controlled trial was conducted in 85 patients indicated for induction of labor and with unfavorable cervices. They were randomly assigned to receive either intravaginal misoprostol (100 mg) or placebo placed in the posterior vaginal fornix. The Bishop score, fetal heart rate and Doppler blood flow velocity waveforms were measured before and 12 h after drug administration. Placenta and decidu were histopathologically observed in some cases. Among 85 patients enrolled, 43 received misoprostol and 42 received placebo. Whereas the mean initial Bishop scores were not significantly different between the two growps, the mean Bishop score in misoprostol group was significantly better than those in placebo group. The mean change in Bishop score was also significantly different (4. 4 for misoprostol versus 1. 0 for placebo,P |
| Databáze: | OpenAIRE |
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