Strontium ranelate promotes increased peri-implant bone formation in ovariectomized rats
| Autor: | Monteiro Ng, Roberta Okamoto, FC Yogui, Pedro Henrique Silva Gomes-Ferreira, Juliana Zorzi Coléte, Fábio Roberto de Souza Batista, Letícia Pitol-Palin, Jaqueline Suemi Hassumi, Ana Cláudia Ervolino-Silva |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Osseointegração medicine.drug_class Osteoporosis chemistry.chemical_element 030209 endocrinology & metabolism Bone tissue Osseointegration lcsh:Social Sciences 03 medical and health sciences 0302 clinical medicine Estrôncio Strontium ranelate Internal medicine Hueso medicine Osso Osteoporose lcsh:Science (General) General Environmental Science lcsh:LC8-6691 Strontium Estroncio lcsh:Special aspects of education Bone 030206 dentistry medicine.disease lcsh:H Endocrinology medicine.anatomical_structure chemistry Estrogen Ovariectomized rat General Earth and Planetary Sciences Implant Osseointegracion lcsh:Q1-390 medicine.drug |
| Zdroj: | Research, Society and Development; Vol. 9 No. 10; e7539109092 Research, Society and Development; Vol. 9 Núm. 10; e7539109092 Research, Society and Development; v. 9 n. 10; e7539109092 Research, Society and Development Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI Research, Society and Development, Vol 9, Iss 10 (2020) |
| ISSN: | 2525-3409 |
| Popis: | This study aimed to evaluate the systemic effect of strontium ranelate (SR) on peri-implant bone tissue. Thirty-six adult rats were divided into three experimental groups: sham (SHAM), ovariectomized (OVX) and ovariectomized rats treated with strontium ranelate (OVX-Sr). Strontium ranelate (625mg/kg) was administered by oral gavage on a daily basis. The implants were installed on the tibiae. The euthanasia occurred 42 and 60 days after the implants were installed, and the biomechanical (reverse torque); PCR-RT; histological; immunohistochemical; confocal microscopy and histometric analysis were performed. Quantitative data was subjected to statistical tests with significance level set at p |
| Databáze: | OpenAIRE |
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