Deformation Response of Catenated DNA Networks in a Planar Elongational Field
Autor: | Beatrice W. Soh, Patrick S. Doyle |
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Rok vydání: | 2022 |
Předmět: |
Quantitative Biology::Biomolecules
Materials science Polymers and Plastics Field (physics) Organic Chemistry technology industry and agriculture Deformation (meteorology) Inorganic Chemistry chemistry.chemical_compound Planar stomatognathic system chemistry Chemical physics Kinetoplast parasitic diseases Materials Chemistry DNA |
Zdroj: | MIT web domain |
ISSN: | 2161-1653 |
Popis: | Copyright © 2020 American Chemical Society. A kinetoplast is a complex catenated DNA network that bears resemblance to a two-dimensional polymeric system. In this work, we use single-molecule experiments to study the transient and steady-state deformation of kinetoplasts in a planar elongational field. We demonstrate that kinetoplasts deform in a stagewise manner and undergo transient deformation at large strains, due to conformational rearrangements from an intermediate metastable state. Kinetoplasts in an elongational field achieve a steady-state deformation that depends on strain rate, akin to the deformation of linear polymers. We do not observe an abrupt transition between the nondeformed and deformed states of a kinetoplast, in contrast to the coil-stretch transition for a linear polymer. |
Databáze: | OpenAIRE |
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