| Autor: |
Takashi Itahashi, Ayumu Yamashita, Yuji Takahara, Noriaki Yahata, Yuta Y. Aoki, Junya Fujino, Yujiro Yoshihara, Motoaki Nakamura, Ryuta Aoki, Haruhisa Ohta, Yuki Sakai, Masahiro Takamura, Naho Ichikawa, Go Okada, Naohiro Okada, Kiyoto Kasai, Saori C. Tanaka, Hiroshi Imamizu, Nobumasa Kato, Yasumasa Okamoto, Hidehiko Takahashi, Mitsuo Kawato, Okito Yamashita, Ryu-ichiro Hashimoto |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
bioRxiv |
| DOI: |
10.1101/2023.03.26.534053 |
| Popis: |
Autism spectrum disorder (ASD) is a lifelong condition, and its underlying biological mechanisms remain elusive. The complexity of various factors, including inter-site and development-related differences, makes it challenging to develop generalizable neuroimaging-based biomarkers for ASD. This study used a large-scale, multi-site dataset of 730 Japanese adults to develop a generalizable neuromarker for ASD across independent sites (U.S., Belgium, and Japan) and different developmental stages (children and adolescents). Our adult ASD neuromarker achieved successful generalization for the US and Belgium adults (area under the curve [AUC] = 0.70) and Japanese adults (AUC = 0.81). The neuromarker demonstrated significant generalization for children (AUC = 0.66) and adolescents (AUC = 0.71; allP |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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