Therapeutic potential of flavonoids in inflammatory bowel disease: A comprehensive review
| Autor: | Antoni Sureda, Leo R. Fitzpatrick, Anupam Bishayee, Seyed Mohammad Nabavi, Farzaneh Hadjiakhoondi, Behrad Darvishi, Ali Salaritabar, Seyed Fazel Nabavi, Azadeh Manayi |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
colitis Colon Anti-Inflammatory Agents Inflammation Disease Review Bioinformatics Inflammatory bowel disease Neuroprotection ensayos clínicos como asunto 03 medical and health sciences 0302 clinical medicine Intestinal mucosa Crohn Disease Gastrointestinal tract flavonoides medicine Adjuvant therapy Animals Intestinal Mucosa Flavonoids Clinical Trials as Topic business.industry resultado del tratamiento Gastroenterology food and beverages Polyphenols General Medicine medicine.disease antiinflamatorios Ulcerative colitis Disease Models Animal 030104 developmental biology Treatment Outcome 030220 oncology & carcinogenesis mucosa intestinal enfermedad de Crohn animales Colitis Ulcerative medicine.symptom Metabolic syndrome Antioxidant business |
| Zdroj: | World Journal of Gastroenterology |
| ISSN: | 2219-2840 |
| Popis: | The inflammatory process plays a central role in the development and progression of numerous pathological situations, such as inflammatory bowel disease (IBD), autoimmune and neurodegenerative diseases, metabolic syndrome, and cardiovascular disorders. IBDs involve inflammation of the gastrointestinal area and mainly comprise Crohn's disease (CD) and ulcerative colitis (UC). Both pathological situations usually involve recurring or bloody diarrhea, pain, fatigue and weight loss. There is at present no pharmacological cure for CD or UC. However, surgery may be curative for UC patients. The prescribed treatment aims to ameliorate the symptoms and prevent and/or delay new painful episodes. Flavonoid compounds are a large family of hydroxylated polyphenolic molecules abundant in plants, including vegetables and fruits which are the major dietary sources of these compounds for humans, together with wine and tea. Flavonoids are becoming very popular because they have many health-promoting and disease-preventive effects. Most interest has been directed towards the antioxidant activity of flavonoids, evidencing a remarkable free-radical scavenging capacity. However, accumulating evidence suggests that flavonoids have many other biological properties, including anti-inflammatory, antiviral, anticancer, and neuroprotective activities through different mechanisms of action. The present review analyzes the available data about the different types of flavonoids and their potential effectiveness as adjuvant therapy of IBDs. |
| Databáze: | OpenAIRE |
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