Modeling the mechanics of tissue-engineered human heart valve leaflets
| Autor: | Carlijn V. C. Bouten, Frank P. T. Baaijens, Anita Mol, Niels J. B. Driessen |
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| Přispěvatelé: | Soft Tissue Biomech. & Tissue Eng. |
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Tissue engineered
Materials science Tissue Engineering Finite Element Analysis Rehabilitation Biomedical Engineering Biophysics Uniaxial tension Human heart ComputingMilieux_LEGALASPECTSOFCOMPUTING Mechanics Models Biological Finite element method Biomechanical Phenomena medicine.anatomical_structure Tissue engineering Heart Valve Prosthesis Pressure load medicine Humans Orthopedics and Sports Medicine Heart valve Elastic modulus Biomedical engineering |
| Zdroj: | Mate Poster Award 2005 : 10th Annual Poster Contest Journal of Biomechanics, 40(2), 325-334. Elsevier Pure TUe |
| ISSN: | 0021-9290 |
| DOI: | 10.1016/j.jbiomech.2006.01.009 |
| Popis: | Mathematical models can provide valuable information to assess and evaluate the mechanical behavior of tissue-engineered constructs. In this study, a structurally based model is applied to describe and analyze the mechanics of tissue-engineered human heart valve leaflets. The results from two orthogonal uniaxial tensile tests are used to determine the model parameters of the constructs after two, three and four weeks of culturing. Subsequently, finite element analyses are performed to simulate the mechanical response of the engineered leaflets to a pressure load. The stresses in the leaflets induced by the pressure load increase monotonically with culture time due to a decrease in the construct's thickness. The strains, on the other hand, eventually decrease as a result of an increase in the elastic modulus. Compared to native porcine leaflets, the mechanical response of the engineered tissues after four weeks of culturing is more linear, stiffer and less anisotropic. (c) 2006 Elsevier Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
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