Coriander Alleviates 2,4-Dinitrochlorobenzene-Induced Contact Dermatitis-Like Skin Lesions in Mice
| Autor: | Soonmin Lim, Yeomoon Sim, Myung Sook Oh, Wonil Lee, Gunhyuk Park, Hyo Geun Kim |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
Erythema Coriandrum Medicine (miscellaneous) Inflammation Dermatitis Contact 2 4-Dinitrochlorobenzene Proinflammatory cytokine Mice chemistry.chemical_compound Dinitrochlorobenzene medicine Animals Humans Skin Mice Inbred ICR Interleukin-13 Nutrition and Dietetics biology Plant Extracts business.industry Interleukin medicine.disease biology.organism_classification chemistry Interleukin 13 Immunology Interleukin-4 medicine.symptom Full Communications business Contact dermatitis |
| Zdroj: | Journal of Medicinal Food. 17:862-868 |
| ISSN: | 1557-7600 1096-620X |
| DOI: | 10.1089/jmf.2013.2910 |
| Popis: | Contact dermatitis (CD) is a pattern of inflammatory responses in the skin that occurs through contact with external factors. The clinical picture is a polymorphic pattern of skin inflammation characterized by a wide range of clinical features, including itching, redness, scaling, and erythema. Coriandrum sativum L. (CS), commonly known as coriander, is a member of the Apiaceae family and is cultivated throughout the world for its nutritional and culinary values. Linoleic acid and linolenic acid in CS have various pharmacological activities. However, no study of the inhibitory effects of CS on CD has been reported. In this study, we demonstrated the protective effect of CS against 2,4-dinitrochlorobenzene-induced CD-like skin lesions. CS, at doses of 0.5–1%, applied to the dorsal skin inhibited the development of CD-like skin lesions. Moreover, the Th2-mediated inflammatory cytokines, immunoglobulin E, tumor necrosis factor-α, interferon-γ, interleukin (IL)-1, IL-4, and IL-13, were significantly reduced. In addition, CS increased the levels of total glutathione and heme oxygenase-1 protein. Thus, CS can inhibit the development of CD-like skin lesions in mice by regulating immune mediators and may be an effective alternative therapy for contact diseases. |
| Databáze: | OpenAIRE |
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